Innovation in Research: Drivers and pressures Professor Trevor McMillan PhD FRCR (Hon) MRCP (Hon) FRSB Vice-Chancellor Keele University The ideal sunscreen? Sunlight
Safe tan Sunscreen No biomolecular damage + melanin stimulation + Vitamin D production Project Safe Tan (A Fictitious University, NHS, Business collaboration) Principle proven in vitro
Authorisation by: University NHS Company Award of Funding Recruitment and delivery of
trial Dissemination of results Medical Innovation: between standard practice and clinical research. Criticized for doing something V
Criticized for NOT doing something How much evidence is needed for the application of innovation to be appropriate? Personalized medicine: A medical model that separates patients into different groups - with medical decisions, practices, interventions and/or products being tailored to the individual
patient based on their predicted response or risk of disease Therapeutic ratio: Effect on tumour V Effect on normal tissue Individuals vary in their sensitivity to ionising radiation.
Ataxia telangiectasia 1 in 300 000 progressive cerebellar ataxia, ocular motor dyspraxia, dysarthria deficiency in cell-mediated immunity thymic hypoplasia, hypogonadism, growth retardation, telangiectasia increased radiosensitivity 10% of homozygotes develop a malignancy in
childhood or early adulthood 6 4 F re q u e n c y Sensitivity of fibroblasts from BRCA1 families
High dose-rate response 2 0 4 Low dose-rate response
2 0 5 6 7 D0.01 (gray)
8 9 Final thoughts Innovative Practice should not be a substitute for full randomised clinical trials where such trials possible. But some major trends in treatments (e.g. personalisation) may not be suitable for standard trial design and/or standard
statistics. Therefore a innovation framework that protects patients and clinicians is likely to become increasingly required.
Use different sets of measurements to define apex of triangle (adopted from Peskin) Also have eK (CP in KL system) Measuring a Using Bo rp p+p-po A Dalitz Plot analysis gives both sin(2a) and cos(2a) (Snyder & Quinn) Measured branching...
ANALYZING BANK PERFORMANCE: USING THE UBPR Chapter 2 Balance Sheet Assets = Liabilities + Equity Balance sheet figures are calculated at a particular point in time and thus represent stock values. Bank Assets Cash and due from banks Vault cash,...
One Call Solution Center: The goal of this initiative is to offer defendants 24-hour access to court services. These options include requesting DSC, Deferred Adjudication, submission of compliance documents, payment of fines, case resets, and general court/case information.
3rd year teaching science at Altadena. Expecting a little boy in November. Students use scientific processes to: Question. ... energy. Energy. Energy Continued. Compare the pros and cons of alternate energy sources and the technology behind them.
Figure 8: Average measurements of the dataset derived for the Thwaites Glacier region utilizing data collected from the snow radar. The "short segment" has a variation in mean accumulation of 0.40 and a standard deviation of 0.052. The "long" segment...