Vice-Chancellor's Visit School

Innovation in Research: Drivers and pressures Professor Trevor McMillan PhD FRCR (Hon) MRCP (Hon) FRSB Vice-Chancellor Keele University The ideal sunscreen? Sunlight

Safe tan Sunscreen No biomolecular damage + melanin stimulation + Vitamin D production Project Safe Tan (A Fictitious University, NHS, Business collaboration) Principle proven in vitro

Authorisation by: University NHS Company Award of Funding Recruitment and delivery of

trial Dissemination of results Medical Innovation: between standard practice and clinical research. Criticized for doing something V

Criticized for NOT doing something How much evidence is needed for the application of innovation to be appropriate? Personalized medicine: A medical model that separates patients into different groups - with medical decisions, practices, interventions and/or products being tailored to the individual

patient based on their predicted response or risk of disease Therapeutic ratio: Effect on tumour V Effect on normal tissue Individuals vary in their sensitivity to ionising radiation.

Ataxia telangiectasia 1 in 300 000 progressive cerebellar ataxia, ocular motor dyspraxia, dysarthria deficiency in cell-mediated immunity thymic hypoplasia, hypogonadism, growth retardation, telangiectasia increased radiosensitivity 10% of homozygotes develop a malignancy in

childhood or early adulthood 6 4 F re q u e n c y Sensitivity of fibroblasts from BRCA1 families

High dose-rate response 2 0 4 Low dose-rate response

2 0 5 6 7 D0.01 (gray)

8 9 Final thoughts Innovative Practice should not be a substitute for full randomised clinical trials where such trials possible. But some major trends in treatments (e.g. personalisation) may not be suitable for standard trial design and/or standard

statistics. Therefore a innovation framework that protects patients and clinicians is likely to become increasingly required.

Recently Viewed Presentations

  • BTeV Physics Reach LHC 2003 Symposium K. Honscheid

    BTeV Physics Reach LHC 2003 Symposium K. Honscheid

    Use different sets of measurements to define apex of triangle (adopted from Peskin) Also have eK (CP in KL system) Measuring a Using Bo rp p+p-po A Dalitz Plot analysis gives both sin(2a) and cos(2a) (Snyder & Quinn) Measured branching...
  • Latin & Greek Roots

    Latin & Greek Roots

    One year after the crash of the stock market, the economy remains stuck in deep . malaise. Synonym: boredom . Words from "mal" ... Antonym: affirm . Words from "Neg" ...
  • Analyzing Bank Performance: Using the UBPR

    Analyzing Bank Performance: Using the UBPR

    ANALYZING BANK PERFORMANCE: USING THE UBPR Chapter 2 Balance Sheet Assets = Liabilities + Equity Balance sheet figures are calculated at a particular point in time and thus represent stock values. Bank Assets Cash and due from banks Vault cash,...
  • Presented By: Lloyd Waguespack, Deputy Chief of Staff,

    Presented By: Lloyd Waguespack, Deputy Chief of Staff,

    One Call Solution Center: The goal of this initiative is to offer defendants 24-hour access to court services. These options include requesting DSC, Deferred Adjudication, submission of compliance documents, payment of fines, case resets, and general court/case information.
  • PowerPoint 演示文稿

    PowerPoint 演示文稿

    The Objective. Firstly, when training G, we replace the objective function given in Equation 5 with the l2-loss between Ar and Arˆ, to maintain a reasonable scale of the gradient.
  • Science Curriculum - Kyrene School District

    Science Curriculum - Kyrene School District

    3rd year teaching science at Altadena. Expecting a little boy in November. Students use scientific processes to: Question. ... energy. Energy. Energy Continued. Compare the pros and cons of alternate energy sources and the technology behind them.
  • Developing a Method for Estimating Accumulation Rates using

    Developing a Method for Estimating Accumulation Rates using

    Figure 8: Average measurements of the dataset derived for the Thwaites Glacier region utilizing data collected from the snow radar. The "short segment" has a variation in mean accumulation of 0.40 and a standard deviation of 0.052. The "long" segment...
  • SSRAA RETURNS CONTRIBUTION ESTIMATES 2016 Final Coho Release

    SSRAA RETURNS CONTRIBUTION ESTIMATES 2016 Final Coho Release

    2016 SSRAA Chum Contribution By Site and Brood to Common Property Traditional Fisheries District 101-108