Lupine- "Crooked Calf Disease"

Lupine- "Crooked Calf Disease"

Lupine- Crooked Calf Disease Can it be related to birth defects in other species? Case Problem Overview Lupine caused significant calf losses in the Western United States (4,000+ calves from 12,000 cows died in one county) New human baby born in mountainous backcountry of NW California

severe bone deformities in arms and hands partial absence of forearm bones absence of thumbs medical history indicates deformities were not the result of genetics Goats on the farm gave birth to deformed kids Pregnant bitch was fed goats milk and had a litter

of deformed puppies Pregnant woman also drank goats milk during pregnancy What is Crooked Calf Disease? characterized by bone abnormalities in the forelimbs, spine, and skull can be directly attributed to a pregnant mothers ingestion of a specific lupine alkaloid, anagyrine the alkaloids act as a sedative, keeping the fetus in an abnormal position, so that it continues to grow while fixed in that position. this causes the bone

abnormalities.3 Hypothesis We hypothesize that there is a relation between the birth defects of the human baby, goats, and dogs to the lupine induced crooked calf disease. symptoms are similar Goats grazing may have ingested the lupine alkaloid, which allowed the toxin in their system it seems to be transmittable through milk evidenced by the fact that both the woman and bitch

drank the goats milk and had deformed offspring Evidence to support Hypothesis Lupine ingestion is widely accepted as the cause of crooked calf disease No direct evidence available between lupine and goats Tests could be run to detect the presence of anagyrine in goats milk it has been found that when goats are fed lupine seeds, anagyrine can be detected in the milk almost immediately.2

Investigations in test animals to determine how much of the anagyrine needs to be transferred to cause abnormalities Conclusions Circumstances are too coincidental to be three separate, isolated incidents appears to support hypothesis References 1.http://www.wisc.edu/ansci_repro/lab/lab12_03/ lab12_cases/case7_goat.htm

2. Kilgore, Wendell W., Crosby, Donald G., Craigmill, Arthur L., and Poppen, Norman K. < http://extoxnet.orst.edu/newsletters/n23_81.htm> 3. < http://www.vetmed.wsu.edu/depts-fdiu/CrookCalf. asp >

Recently Viewed Presentations

  • ITER Test Blanket Module (TBM) Current U.S. Designs,

    ITER Test Blanket Module (TBM) Current U.S. Designs,

    DCLL Material R&D for Power Plants (cont'd) Common issues for both B1 and B2 cases For both kinds of power plants, the following issues have to be addressed by the material program: Qualification of the RAFS and its welds for...
  • Bangladesh Climate-Resilient Ecosystem Curriculum (BACUM) Module 2: REDD+

    Bangladesh Climate-Resilient Ecosystem Curriculum (BACUM) Module 2: REDD+

    Safeguards have a wide remit and can apply to projects, a set of projects or programmes, as well as act as policies. Safeguards differ from standards, which are 'objectives to be achieved' UNFCCC REDD+ safeguards are atypical safeguards as they...
  • Workshop on Demand Charges and Proposed Alternatives Masoud

    Workshop on Demand Charges and Proposed Alternatives Masoud

    * PFR was filed by CALSSA, SEIA, Enel X, CESA, Engie, OhmConnect and Stem. Question from the Commission: Do SDG&E's current Demand Charges align with Commission policies? Peak load shifting and other grid support objectives. Cost causation principles in rate...
  • IntelliFest 2012 International Conference on Reasoning Technologies INTELLIGENCE

    IntelliFest 2012 International Conference on Reasoning Technologies INTELLIGENCE

    Paul started his professional career as driller at Neddrill an oil and gas exploration contracting company in the Netherlands. There he moved into IT, and has developed into a senior consultant with 25 years of interfacing with Executive Management Teams.
  • Indiana Department of Veterans Affairs

    Indiana Department of Veterans Affairs

    Indiana Department of Veterans AffairsSTATE APPROVING AGENCY. Responsible for approving Institutions of Higher Learning (IHL),Non College Degree Programs (NCD), On the Job Training and Apprenticeship Programs, Licensing and Certification, Flight Schools, and Entrepreneurship Training for veterans to use their GI...
  • Chapter 5 Civil Law &amp; Procedure

    Chapter 5 Civil Law & Procedure

    Crime is a punishable offense against society. When a crime occurs, society (acting through police and prosecutors) attempts to identify, arrest, prosecute, and punish the criminal. These efforts are designed to protect society
  • Unit # 5 Cardiovascular Disease - SFU.ca

    Unit # 5 Cardiovascular Disease - SFU.ca

    Unit # 5 Cardiovascular Disease Cardiovascular Disease Overview #1 cause of mortality in Canada Laboratory Centre for Disease Control; Statistics Canada, 1997 Cardiovascular Disease Overview Refers to diseases of the heart ("cardio") and blood vessels ("vascular") Typically affects the ability...
  • Propaganda - Henry County School District

    Propaganda - Henry County School District

    Propaganda. Definition. techniques used to influence opinions, emotions, attitudes or behavior. Purpose: to benefit the sponsor . to persuade . ... Transfer. Positive feelings or desires are connected to a product and user.